A pilot study evaluating dosing tolerability of 17α-estradiol in male common marmosets (Callithrix jacchus).

ABSTRACT: 17α-estradiol extends healthspan and lifespan in male mice without significant feminization or deleterious effects on reproductive function, making it a candidate for human translation. However, studies in animal models that more accurately replicate human physiology are necessary to establish 17α-estradiol dosing standards for clinical trials. This study evaluated the tolerability of 17α-estradiol treatment in the common marmoset over a short treatment duration. We found that male marmosets tolerated two dosing regimens (0.37-0.47 or 0.62-0.72 mg/kg/day) as evidenced by the absence of gastrointestinal distress, changes in vital signs, or overall health conditions. 17α-estradiol treatment mildly decreased body mass, adiposity, and glycosylated hemoglobin, although these changes were not st

SUBMITTER: Sathiaseelan R 

PROVIDER: S-EPMC11872862 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature