Association of sarcopenia with regional brain atrophy and white matter lesions in a general older population: the Hisayama Study.

ABSTRACT: Sarcopenia has been reported to be associated with cognitive decline and the risk of dementia. However, few studies have addressed the association between sarcopenia and brain morphological changes in the general population. A total of 1373 community-dwelling participants aged ≥ 65 years underwent brain MRI. Sarcopenia was defined based on the Asian Working Group for Sarcopenia's criteria. The pattern of regional gray matter volume loss associated with sarcopenia were assessed using a voxel-based morphometry (VBM) analysis. Regional brain volumes, intracranial volumes (ICV), and white matter lesions volumes (WMLV) were also measured using FreeSurfer. An analysis of covariance was used to examine the associations of sarcopenia with regional brain volumes in proportion to ICV. Of the partici

SUBMITTER: Tajimi T 

PROVIDER: S-EPMC11872879 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature