Acute hypoxia modulate macrophage phenotype accompanied with transcriptome re-programming and metabolic re-modeling.

ABSTRACT:

Introduction

Macrophages, which tend to aggregate in the hypoxic regions of tissues, have a significant impact on disease progression and outcome because of their plastic responsiveness to hypoxia, particularly in the early stages. Understanding macrophages'participation in hypoxia-related disorders requires demonstrating the impact of acute hypoxia on their survival, phenotype, and function.

Methods

Here we conducted a systematic evaluation of macrophage responses to hypoxia over 24 and 48 h including cell growth and activity, inflamatory response, macrophage polarization and transcriptional and metabolic changes.

Results

We found that acute hypoxia suppresses macrophage proliferation and phagocytosis function with a parallel change of transcriptome re-programming an

SUBMITTER: Sun B 

PROVIDER: S-EPMC11872928 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature