Comprehensive analysis of immunogenic cell death-related genes in liver ischemia-reperfusion injury.

ABSTRACT:

Background

Liver ischemia-reperfusion injury (LIRI) is a critical condition after liver transplantation. Understanding the role of immunogenic cell death (ICD) may provide insights into its diagnosis and potential therapeutic targets.

Methods

Differentially expressed genes (DEGs) between LIRI and normal samples were identified, and pathway enrichment analyses were performed, followed by immune infiltration assessment through the CIBERSORT method. The consensus clustering analysis was conducted to separate LIRI clusters and single-sample Gene Set Enrichment Analysis (ssGSEA) was used to analyze the distinct immune states between clusters. Weighted Gene Co-Expression Network Analysis (WGCNA) was employed to identify hub genes associated with ICD. To establish diagnostic models

SUBMITTER: Lu K 

PROVIDER: S-EPMC11872941 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature