Prediction of vedolizumab efficacy in ulcerative colitis: a nomogram incorporating pathological feature and serological marker.

ABSTRACT: Vedolizumab (VDZ) is a humanized, gut-selective biologic used in the treatment of ulcerative colitis (UC). However, data on predictive factors for treatment response are limited. This study aims to develop a nomogram to predict VDZ treatment responsiveness in UC. We retrospectively collected clinical data from patients with moderate-to-severe active UC who received VDZ induction therapy at Chongqing General Hospital from December 2020 to March 2024. Full-slide images of colon biopsies from UC patients prior to VDZ treatment were analyzed to quantify mean mucosal eosinophil density (MMED). Based on clinical response 14-week post-treatment, patients were categorized into responsive and non-responsive groups. In total, 84 UC patients were analyzed, with 58 responding to VDZ treatment and 26 n

SUBMITTER: Wang T 

PROVIDER: S-EPMC11872978 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature