Genetic determinants of inflammatory cytokines and their causal relationship with inflammatory disorders of breast: a two-sample Mendelian randomization study.

ABSTRACT: This study utilized two-sample MR to investigate causality between genetically predicted inflammatory markers and the risk of IDB. This research leveraged publicly available GWAS summary statistics to collect data on inflammatory cytokines and IDB. The IVW method was primarily employed for causal inference, supplemented by weighted median, mode-based estimation, and MR-Egger regression. Stringent sensitivity methods included Cochran's Q test, MR-Egger regression, MR-PRESSO, and leave-one-out analyses to assess the robustness of the findings. This study selected 452 instrument variables (IVs) related to inflammatory factors. The IVW analysis revealed that GROa and RANTES/CCL5 exhibited causal relationships with IDB. Additionally, after removing outliers, significant causal associations were

SUBMITTER: Wei H 

PROVIDER: S-EPMC11873064 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature