Alteration of chromatin states perturb the transcription regulation of gene during hydronephrosis.

ABSTRACT:

Background

Gene expression is abnormal in disease compared to normal tissue same as the regulatory elements. Regulatory element binding with transcription factors managed transcription of gene, which usually require chromatin accessible.

Methods

To reveal potential epigenetic mechanism during hydronephrosis, we first used RNA-seq to finger out the disfunction genes during hydronephrosis, then combined with ATAC-seq, and BS-seq to reveal the related disfunction regulatory elements.

Results

Finally, we find that 860 differentially genes and 2429 dynamic chromatin open regions between normal and hydronephrosis tissue. Though, most of disfunction genes and regulatory elements significantly enriched in chronic kidney disease GO term, only small part of regulatory element t

SUBMITTER: Wang XH 

PROVIDER: S-EPMC11873066 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature