How modulation of the tumor microenvironment drives cancer immune escape dynamics.

ABSTRACT: Metastatic disease is the leading cause of cancer-related death, despite recent advances in therapeutic interventions. Prior modeling approaches have accounted for the adaptive immune system's role in combating tumors, which has led to the development of stochastic models that explain cancer immunoediting and tumor-immune co-evolution. However, cancer immune-mediated dormancy, wherein the adaptive immune system maintains a micrometastatic population by keeping its growth in check, remains poorly understood. Immune-mediated dormancy can significantly delay the emergence (and therefore detection) of metastasis. An improved quantitative understanding of this process will thereby improve our ability to identify and treat cancer during the micrometastatic period. Here, we introduce a generalize

SUBMITTER: Shrestha P 

PROVIDER: S-EPMC11873109 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature