Serotonin attenuates tumor necrosis factor-induced intestinal inflammation by interacting with human mucosal tissue.

ABSTRACT: The intestine hosts the largest immune system and peripheral nervous system in the human body. The gut‒brain axis orchestrates communication between the central and enteric nervous systems, playing a pivotal role in regulating overall body function and intestinal homeostasis. Here, using a human three-dimensional in vitro culture model, we investigated the effects of serotonin, a neuromodulator produced in the gut, on immune cell and intestinal tissue interactions. Serotonin attenuated the tumor necrosis factor-induced proinflammatory response, mostly by affecting the expression of chemokines. Serotonin affected the phenotype and distribution of tissue-migrating monocytes, without direct contact with the cells, by remodeling the intestinal tissue. Collectively, our results show that seroto

SUBMITTER: Bosakova V 

PROVIDER: S-EPMC11873120 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature