Increased zinc finger protein zFOC1 transcripts in gastric cancer compared with normal gastric tissue.

ABSTRACT: BACKGROUND:Screening of cDNA arrays of the IMAGE library identified human zFOC1 as a differentially expressed cDNA that was upregulated in KATO III gastric cancer cells following stimulation with the gastric pathogen Helicobacter pylori. AIMS:To determine the expression of zFOC1 in gastric mucosa with and without H pylori infection and in patients with gastric cancer. RESULTS:zFOC1 is localised on chromosome 12q24.3 and encodes a zinc finger protein. Expression studies in human H pylori infected and uninfected gastric biopsies, gastric tumours, and gastric cancer cell lines revealed that zFOCI gene transcripts are significantly higher in gastric cancer than in non-cancerous gastric tissues. CONCLUSIONS:The zFOC1 gene appears to be a tumour marker associated with gastric cancer.

SUBMITTER: Stephen RL 

PROVIDER: S-EPMC1187313 | biostudies-literature | 2003 Jun

REPOSITORIES: biostudies-literature