Activin E is a new guardian protecting against hepatic steatosis via inhibiting lipolysis in white adipose tissue.

ABSTRACT: Hepatic endoplasmic reticulum (ER) stress is implicated in the development of steatosis and its progression to nonalcoholic steatohepatitis (NASH). The ER in the liver can sustain metabolic function by activating defense mechanisms that delay or prevent the progression of nonalcoholic fatty liver disease (NAFLD). However, the precise mechanisms by which the ER stress response protects against NAFLD remain largely unknown. Recently, activin E has been linked to metabolic diseases such as insulin resistance and NAFLD. However, the physiological conditions and regulatory mechanisms driving hepatic Inhbe expression (which encodes activin E) as well as the metabolic role of activin E in NAFLD require further investigation. Here we found that hepatic Inhbe expression increased under prolonged fa

SUBMITTER: Park SY 

PROVIDER: S-EPMC11873131 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature