Validation of a whole blood coagulometer sensitive to the direct oral anticoagulants.

ABSTRACT: Readily available and rapid turn-around, bedside assays to measure the effect of the direct oral anticoagulants (DOACs) are not available. This study evaluates a point-of-care (PoC) coagulometer to assess the anticoagulant effects of the DOACs and low molecular weight heparin. Studies were done in fresh spiked blood from healthy volunteers. PoC coagulometer baseline clotting times were half that of the manual whole blood clotting time (WBCT, legacy method) and exhibited a sensitivity to DOAC anticoagulation approximately twice that of WBCT. All %CV values for both methods were < 10% with most being < 5% indicating acceptable precision of both methods. R² values for both clotting time and percent rise from baseline were > 0.98 indicating a strong correlation between the two metho

SUBMITTER: Bakhru SH 

PROVIDER: S-EPMC11873143 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature