Targeting the splicing factor SNRPB inhibits endometrial cancer progression by retaining the POLD1 intron.

ABSTRACT: Dysregulated alternative splicing has been closely linked to the initiation and progression of tumors. Nevertheless, the precise molecular mechanisms through which splicing factors regulate endometrial cancer progression are still not fully understood. This study demonstrated elevated expression of the splicing factor SNRPB in endometrial cancer samples. Furthermore, our findings indicate that high SNRPB expression is correlated with poor prognosis in patients with endometrial cancer. Functionally, SNRPB inhibition hindered the proliferative and metastatic capacities of endometrial cancer cells. Mechanistically, we revealed that SNRPB knockdown decreased POLD1 expression and that POLD1 intron 22 was retained after SNRPB silencing in endometrial cancer cells, as determined via RNA sequencin

SUBMITTER: Li Y 

PROVIDER: S-EPMC11873159 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature