Pretrained transformers applied to clinical studies improve predictions of treatment efficacy and associated biomarkers.

ABSTRACT: Cancer treatment has made significant advancements in recent decades, however many patients still experience treatment failure or resistance. Attempts to identify determinants of response have been hampered by a lack of tools that simultaneously accommodate smaller datasets, sparse or missing measurements, multimodal clinicogenomic data, and that can be interpreted to extract biological or clinical insights. We introduce the Clinical Transformer, an explainable transformer-based deep-learning framework that addresses these challenges. Our framework maximizes data via self-supervised, gradual, and transfer learning, and yields survival predictions surpassing performance of state-of-the-art methods across diverse, independent datasets. The framework's generative capability enables in silico

SUBMITTER: Arango-Argoty G 

PROVIDER: S-EPMC11873189 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature