Systematic biotechnological production of isoprenoid analogs with bespoke carbon skeletons.

ABSTRACT: Natural products are widely used as pharmaceuticals, flavors, fragrances, and cosmetic ingredients. Synthesizing and evaluating analogs of natural products can considerably expand their applications. However, the chemical synthesis of analogs of natural products is severely hampered by their highly complex structures. This is particularly evident in isoprenoids, the largest class of natural products. Here, we develop a yeast cell-based biocatalytic method that enables the systematic biotechnological production of analogs of different classes of isoprenoids (including monoterpenoids, sesquiterpenoids, triterpenoids, and cannabinoids) with additional carbons in their skeletons. We demonstrate the applicability of this approach through two proof-of-concept studies: the biosynthesis of the hig

SUBMITTER: Wang L 

PROVIDER: S-EPMC11873216 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature