Remodeling of the cardiac striatin interactome and its dynamics in the diabetic heart.

ABSTRACT: Diabetic cardiomyopathy (DbCM) is a silent and complex condition involving numerous signaling pathways that impair cardiomyocyte metabolism and cardiac performance. Striatin (STRN) is a multifaceted protein that binds metabolic proteins, yet its role in diabetic heart remains unexplored. Here we characterized the cardiac STRN interactome by performing immunoprecipitation on left ventricle (LV) proteins from control and diabetic hearts (rats treated with streptozotocin for 24 weeks) to dissect its derivative protein complex. Diabetic rats exhibited pathological heart remodeling characterized by increased heart weight/body weight ratio, elevated levels of Atrial Natriuretic Factor (ANF), and altered expression of alpha and beta-myosin heavy chain isoforms. Notably, STRN expression mirrored t

SUBMITTER: Chacar S 

PROVIDER: S-EPMC11873221 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature