Multi-omics integration analysis and association study reveal the potential of ADIPOQ function in gestational diabetes mellitus.

ABSTRACT:

Aim

To investigate the role of ADIPOQ gene in gestational diabetes mellitus (GDM).

Methods

We genotyped single nucleotide polymorphisms (SNPs) rs266729 and rs1501299 within the ADIPOQ gene in a cohort of 1157 pregnant women of north Chinese Han ethnicity. This cohort comprised 560 pregnant women diagnosed with GDM and 597 pregnant women who exhibited normal oral glucose tolerance test at 24-28 weeks' gestation. All participants were recruited from the Department of Obstetrics and Gynecology at the Second Affiliated Hospital of Harbin Medical University. Additionally, we used conventional bioinformatics analysis methods to conduct multi-omics analysis (transcriptome, epigenome, and single-cell level) of ADIPOQ-regulated GDM.

Results

The systolic blood flow velocity/dia

SUBMITTER: Li X 

PROVIDER: S-EPMC11873246 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature