The relationship between genetic prediction of 486 blood metabolites and the risk of COPD: mendelian randomization study.

ABSTRACT: Metabolic disorders are an important feature of chronic lung disease. Patients diagnosed with chronic obstructive pulmonary disease (COPD) have been found to experience metabolic disorders. Nonetheless, evidence on the causal role of circulating metabolites in promoting or preventing COPD is still lacking. Conducting a methodical examination on the causal connection between blood metabolites and COPD can aid in identifying fresh objectives for the screening and prevention of COPD. Therefore, we performed a two-sample Mendelian randomization (MR) analysis to evaluate the causal association between COPD and 486 blood metabolites.We used two-sample MR techniques and genome-wide association study (GWAS) data to evaluate the correlation between COPD and 486 serum metabolites. To evaluate the ca

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC11873255 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature