Novel tissue biomarker candidates to predict both deep venous thrombosis and healing outcome after Achilles tendon rupture.

ABSTRACT: Deep venous thrombosis (DVT) and poor long-term patient outcomes frequently occur in patients with Achilles tendon rupture (ATR). Biomarkers for DVT and their possible relationship to long-term healing outcomes remain unexplored. To identify DVT biomarkers from proteomic profiles during the inflammatory and proliferative healing stages and assess their associations with one-year healing outcomes after surgical repair of ATR. A cohort of 53 patients undergoing standardized ATR repair from previous clinical trials was investigated. Intraoperative inflammatory-stage tendon biopsies were obtained from 40 patients, and tendon microdialysates from 28 patients were collected two weeks later during the proliferative stage. Liquid chromatography-tandem mass spectrometry proteomic profiles were link

SUBMITTER: Saarensilta A 

PROVIDER: S-EPMC11873306 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature