Anti-inflammatory actions of ripasudil ameliorate experimental autoimmune uveoretinitis in the acute phase.

ABSTRACT:

Introduction

Rho-associated protein kinases (ROCKs) are a key regulator of T cell function, influencing a wide range of processes from activation to differentiation. Experimental autoimmune uveoretinitis (EAU) is an animal model of human non-infectious uveitis. This study aimed to evaluate the suppressive effects of ripasudil, a ROCK inhibitor, on ocular inflammation when administered from the onset of EAU and to elucidate the underlying mechanisms of its inhibitory effects.

Methods

EAU was induced in wild-type C57BL/6 mice by immunisation with IRBP peptide. Ripasudil or its vehicle, PBS, was intraperitoneally administered daily starting from 8 days post-immunisation. Clinical and histopathological examinations and analysis of T cell activation state were conducted. In addit

SUBMITTER: Harimoto K 

PROVIDER: S-EPMC11873326 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature