Lack of neuropsychological effects following short-term subcallosal cingulate gyrus deep brain stimulation in treatment-resistant depression: a randomised crossover study.

ABSTRACT:

Background

The subcallosal cingulate gyrus (SCG) is integral to cognitive function and mood regulation. Open-label SCG deep brain stimulation (DBS) studies demonstrate improvement or stabilisation of cognitive function in treatment-resistant depression (TRD).

Objective

This randomised controlled study aims to evaluate the neuropsychological effects of SCG-DBS.

Methods

35 participants with TRD received active or sham stimulation over two 3-month periods. A neuropsychological battery was administered to assess processing speed, learning and memory, and cognitive flexibility. Composite measures were derived for each domain after Period I. A mixed model for repeated measures analysis was performed for each test, with further analysis of significant measures to determine s

SUBMITTER: Gholamali Nezhad F 

PROVIDER: S-EPMC11873328 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature