Digital twin-enhanced three-organ microphysiological system for studying drug pharmacokinetics in pregnant women.

ABSTRACT:

Background

Pregnant women represent a vulnerable group in pharmaceutical research due to limited knowledge about drug metabolism and safety of commonly used corticosteroids like prednisone due to ethical and practical constraints. Current preclinical models, including animal studies, fail to accurately replicate human pregnancy conditions, resulting in gaps in drug safety and pharmacokinetics predictions. To address this issue, we used a three-organ microphysiological system (MPS) combined with a digital twin framework, to predict pharmacokinetics and fetal drug exposure.

Methods

The here shown human MPS integrated gut, liver, and placenta models, interconnected via the corresponding vasculature. Using prednisone as a model compound, we simulate oral drug administration and

SUBMITTER: Graf K 

PROVIDER: S-EPMC11873563 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature