Genetic variants and mRNA expression levels of <i>KLF4</i> and <i>KLF5</i> with hypertension: A combination of case-control study and cohort study.

ABSTRACT: Hypertension (HT) is a major risk factor for cardiovascular diseases. Krüppel-like factors (KLFs) are important transcription factors in eukaryotes. Studies have reported that KLF4 and KLF5 are correlated with several cardiovascular diseases, but population-based studies on associations between HT and KLF4 or KLF5 have rarely been reported. Therefore, the current study investigated the associations of genetic variants and mRNA expression levels of KLF4 and KLF5 with HT, as well as the effects of antihypertensive drugs on the expression levels of these genes. The associations of one single-nucleotide polymorphism (SNP) in KLF4 and three SNPs in KLF5 with HT were analyzed using a combination of case-control and cohort studies. The study populations were selected f

SUBMITTER: Han X 

PROVIDER: S-EPMC11873589 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature