Macrophage scavenger receptor A1 promotes skeletal muscle regeneration after hindlimb ischemia.

ABSTRACT: The macrophage-mediated inflammatory response is crucial for the recovery of skeletal muscle following ischemia. Therefore, macrophage-based therapeutic targets need to be explored for ischemic disease. In the current study, we found that the mRNA levels of scavenger receptor A1 ( Sr-a1) were elevated in patients with critical limb ischemia, based on an analysis of the Gene Expression Omnibus data. We then investigated the role and underlying mechanisms of macrophage SR-A1 in a mouse hindlimb ischemia (HLI) model. Compared with the Sr-a1 ^fl/fl mice, the Lyz ^Cre/+/ Sr-a1 ^flox/flox ( Sr-a1 ^ΔMΦ) mice showed significantly reduced laser Doppler blood flow in the ischemic limb on day seven after HLI. Consistently, his

SUBMITTER: Wang S 

PROVIDER: S-EPMC11873590 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature