Regulation of histidine metabolism by <i>Lactobacillus Reuteri</i> mediates the pathogenesis and treatment of ischemic stroke.

ABSTRACT: Increasing evidence has underscored the significance of post-stroke alterations along gut-brain axis, while its role in pathogenesis and treatment of ischemic stroke (IS) remains largely unexplored. This study aimed to elucidate the therapeutic effects and action targets of Panax notoginseng saponins (PNS) on IS and explore a novel pathogenesis and treatment strategy of IS via profiling the microbial community and metabolic characteristics along gut-brain axis. Our findings revealed for the first time that the therapeutic effect of PNS on IS was microbiota-dependent. Ischemia/reperfusion (I/R) modeling significantly down-regulated Lactobacilli in rats, and PNS markedly recovered Lactobacilli, particularly Lactobacillus reuteri (L.Reu). Metabolomics

SUBMITTER: Hu K 

PROVIDER: S-EPMC11873608 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature