Effects of Clinical Covariates on Serum miRNA Expression among Women without Ovarian Cancer.

ABSTRACT:

Background

Serum miRNAs are potential biomarkers for ovarian cancer; however, many factors may influence miRNA expression. To understand potential confounders in miRNA analysis, we examined how sociodemographic factors and comorbidities, including known ovarian cancer risk factors, influence serum miRNA levels in women without ovarian cancer.

Methods

Data from 1,576 women from the Mass General Brigham Biobank collected between 2012 and 2019, excluding subjects previously or subsequently diagnosed with ovarian cancer, were examined. Using a focused panel of 179 miRNA probes optimized for serum profiling, miRNA expression was measured by flow cytometry using the Abcam FirePlex assay and correlated with subjects' electronic medical records.

Results

The study population b

SUBMITTER: Wollborn L 

PROVIDER: S-EPMC11873719 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature