Selenoprotein O Promotes Melanoma Metastasis and Regulates Mitochondrial Complex II Activity.

ABSTRACT: Evolutionarily conserved selenoprotein O (SELENOO) catalyzes a posttranslational protein modification known as AMPylation that is essential for the oxidative stress response in bacteria and yeast. Given that oxidative stress experienced in the blood limits survival of metastasizing melanoma cells, SELENOO might be able to affect metastatic potential. However, further work is needed to elucidate the substrates and functional relevance of the mammalian homolog of SELENOO. In this study, we revealed that SELENOO promotes cancer metastasis and identified substrates of SELENOO in mammalian mitochondria. In patients with melanoma, high SELENOO expression was correlated with metastasis and poor overall survival. In a murine model of spontaneous melanoma metastasis, SELENOO deficiency significantl

SUBMITTER: Nascentes Melo LM 

PROVIDER: S-EPMC11873727 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature