Lonidamine, a Novel Modulator for the BvgAS System of Bordetella Species.

ABSTRACT: The Gram-negative bacteria Bordetella pertussis, B. parapertussis, and B. bronchiseptica cause respiratory diseases in various mammals. They share the BvgAS two-component system, which regulates the phenotypic conversion between the virulent Bvg⁺ and avirulent Bvg^- phases. In the BvgAS system, the sensor kinase BvgS senses environmental cues and transduces a phosphorelay signal to the response regulator BvgA, which leads to the expression of Bvg⁺ phase-specific genes, including virulence factor genes. Bacteria grown at 37°C exhibit the Bvg⁺ phenotype. In contrast, at lower than 26°C or in the presence of modulators, such as MgSO₄ and nicotinic acid, the BvgAS system is inactivated, leading bacteria to the avirulent Bvg^- phas

SUBMITTER: Ota N 

PROVIDER: S-EPMC11873758 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature