Thalamic nuclei segmentation from T1-weighted MRI: Unifying and benchmarking state-of-the-art methods.

ABSTRACT: The thalamus and its constituent nuclei are critical for a broad range of cognitive, linguistic, and sensorimotor processes, and are implicated in many neurological and neurodegenerative conditions. However, the functional involvement and specificity of thalamic nuclei in human neuroimaging work is underappreciated and not well studied due, in part, to technical challenges of accurately identifying and segmenting nuclei. This challenge is further exacerbated by a lack of common nomenclature for comparing segmentation methods. Here, we use data from healthy young (Human Connectome Project, n = 100) and older healthy adults, plus those with mild cognitive impairment and Alzheimer's disease (Alzheimer's Disease Neuroimaging Initiative, n = 540), to benchmark four state-of-the-art thalamic seg

SUBMITTER: Williams B 

PROVIDER: S-EPMC11873765 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature