Kidney function and bone mineral density in chronic kidney disease patients.

ABSTRACT:

Background

Bone mineral density (BMD) predicts fracture risk in patients with chronic kidney disease (CKD) and in the general population. However, few studies have investigated risk factors for bone loss in patients with CKD. The aim of this study was to investigate whether renal function is associated with the rate of BMD decline.

Methods

A prospective cohort study included 1006 patients with CKD stages 2-4 between 2011 and 2016. BMD was measured using dual-energy X-ray absorptiometry at baseline and 4 years. The eGFR was measured 2-6 times during the 4-year follow-up. We analyzed the decline in bone mineral density according to CKD stage and further compared the rate of BMD decline according to eGFR trajectories at each stage.

Results

Advanced CKD stage was associat

SUBMITTER: Kang DH 

PROVIDER: S-EPMC11873793 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature