Efficacy and safety of direct oral anticoagulants versus vitamin K antagonists in patients on chronic dialysis.

ABSTRACT:

Background

Clinical trials of direct oral anticoagulants (DOAC) are scarce and inconclusive in patients who are receiving dialysis, for whom DOAC are not labelled in Europe. In a French nationwide registry study of patients on chronic dialysis, we compared the effectiveness and safety of off-label DOAC use vs approved vitamin K antagonist (VKA).

Methods

Data on patients on dialysis were extracted from the French Renal Epidemiology and Information Network (REIN) registry and merged with data from the French national healthcare system database (Système National des Données de Santé, SNDS). Patients on dialysis who had initiated treatment with an oral anticoagulant between 1 January 2012 and 31 December 2020, were eligible for inclusion. The primary safety outcome was the occur

SUBMITTER: Laville SM 

PROVIDER: S-EPMC11873795 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature