Structures and functions of the limited natural polyclonal antibody response to parvovirus infection.

ABSTRACT: Host antibody responses are key components in the protection of animals against pathogens, yet the defining properties of viral antigens and induction of B cell responses that result in varied protection are still poorly understood. Parvoviruses are simple molecular structures that display 60 repeated motifs on their capsid surface, and rapidly induce strong antibody responses that protect animals from infection. We recently showed that following canine parvovirus infection of its natural host, the polyclonal response in the sera contained only two or three dominant antibodies that bound two epitopes on the capsid. Here, we characterize key antibodies present in that immune response, identifying their sequences, defining their binding properties on the capsid by cryoelectron microscopic (c

SUBMITTER: Adu OF 

PROVIDER: S-EPMC11873831 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature