Type III Collagen Promotes Pseudopodium-Driven Cell Migration.

ABSTRACT: The extracellular matrix (ECM), particularly collagen, is acknowledged for its significant impact on cell migration. However, the detailed mechanisms through which it influences pseudopodium formation and cell motility are not yet fully understood. This study delves into the impact of recombinant human type III collagen (hCOL3) on cell migration, specifically focusing on the dynamics of pseudopodia and their contribution to cell motility. The research evaluates the impact of a fragmented form of hCOL3, engineered for the study, on cell motility and pseudopodium behavior using both single-cell and collective-cell migration assays. The results demonstrate that hCOL3 promotes cell migration velocity, augments the effective diffusion coefficient, and enhances directionality in both single-cell

SUBMITTER: Fu R 

PROVIDER: S-EPMC11873850 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature