Can the single-breath alveolar volume be adjusted to estimate true total lung capacity?

ABSTRACT:

Background

Total lung capacity (TLC) measured with single-breath gas diffusion (TLCsb) is systematically lower than TLC measured with whole-body plethysmography (TLCwbp) especially in patients with obstructive defects. We aimed to develop and validate a regression correction equation to reduce the discrepancy between the two measurements of TLC. Second, we compared the ability to detect restriction (reduced TLC) from adjusted TLC measured by single-breath (TLCsb_adj) with gold standard TLCwbp.

Methods

Lung function data from 800 consecutive patients were analysed with multivariable linear regression. A group of 530 were included for model development, and 270 were used for model validation.

Results

TLCsb was found to be on average 1.1 L lower than TLCwbp (

SUBMITTER: Rasmusen SKH 

PROVIDER: S-EPMC11873942 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature