SREBP2-dependent lipid droplet formation enhances viral replication and deteriorates lung injury in mice following IAV infection.

ABSTRACT: Influenza A virus (IAV) is a significant zoonotic pathogen that poses a considerable challenge to public health due to its continuous mutations. Lipid droplets (LDs) have been shown to play an important role in the process of several viral infections. However, their role in IAV infection remains unclear. Here, we found that IAV infection altered the lipid metabolism and increased the content of LDs in the lungs of mice. In vitro, IAV infection also mediated the formation of LDs in A549 cells. Besides, inhibition of the formation of lipid droplets can significantly suppress IAV replication and the release of inflammatory factors, indicating that LDs could facilitate the virus replication and inflammatory response. Furthermore, we discovered that IAV infection could activate the SREBP2, a cr

SUBMITTER: Li X 

PROVIDER: S-EPMC11873989 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature