Survival expectations in melanoma patients: a molecular prognostic model associated with aging.

ABSTRACT:

Background

Aging and long non-coding RNAs (lncRNAs) are research hotspots in melanoma. However, no study has so far explored the relationship between melanoma prognosis and aging-related lncRNAs (ARLs).

Methods

The Cancer Genome Atlas database, the GTEx database, and the HAGR database were used in this study in a combined manner. Univariate and multivariate cox regression analyses were used to screen out lncRNA signatures associated with overall survival (OS) in the primary dataset. The risk scoring model was analyzed by risk stratification and tested internally. The protein expression levels of possible target genes of ARLs were verified by immunohistochemistry analysis in HPA database. Finally, gene enrichment analysis was performed.

Results

In the primary dataset,

SUBMITTER: Zhang N 

PROVIDER: S-EPMC11874052 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature