Investigating the effects of global gene knockout of MrgF on motor performance and pain sensitivity in mice.

ABSTRACT: Mas-related G protein-coupled receptors (Mrgs) are a subset of GPCRs linked to pain modulation. MrgF was identified as an orphan Mrg whose function and ligand remain unclear. In this study, in addition to its expression in the dorsal root ganglia (DRG), the primary afferent center that transmits pain, we identified dense expression of MrgF, particularly concentrated in the Purkinje cell layer of the mouse cerebellum. Given the the important role of Purkinje neurons in both motor modulation and non-motor modulation, including pain processing, we established a MrgF knockout mouse (MrgF^-/-) model and performed a battery of behavioral tests to explore motor performance and assess pain-associated responses. MrgF^-/- mice exhibited no disturbances in coordination and motor b

SUBMITTER: Chen X 

PROVIDER: S-EPMC11874108 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature