<i>Enterobacter hormaechei</i> replaces virulence with carbapenem resistance via porin loss.

ABSTRACT: Pathogenic Enterobacter species are of increasing clinical concern due to the multidrug-resistant nature of these bacteria, including resistance to carbapenem antibiotics. Our understanding of Enterobacter virulence is limited, hindering the development of new prophylactics and therapeutics targeting infections caused by Enterobacter species. In this study, we assessed the virulence of contemporary clinical Enterobacter hormaechei isolates in a mouse model of intraperitoneal infection and used comparative genomics to identify genes promoting virulence. Through mutagenesis and complementation studies, we found two porin-encoding genes, ompC and ompD, to be required for E. hormaechei virulence. These porins imported clinically relevant carbape

SUBMITTER: Perault AI 

PROVIDER: S-EPMC11874173 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature