A natural biological adhesive from slug mucus for wound repair.

ABSTRACT: Slugs could secrete mucus with multifunctional characteristics, such as reversible gelation, mucoadhesiveness, and viscoelasticity, which can be harnessed for multifaceted biotechnological and healthcare applications. The dried mucus (DM) was prepared using slug, which can be adhered to the tissue surface through different types of interactions (lap-shear force, 1.1 N for DM-3 group). The DM-3 further exhibited the highest hemostatic ability as discerned in a liver trauma injury model (hemostasis time, <15 s), biocompatibility and biodegradability (an insignificant residue at 4 weeks) in vivo, and considerably improved skin repair in full-thickness excisional wounds (wound closure, 96.2 % at day 14). Taken together, slug's mucus can be easily prepared with an economic and an eco-fri

SUBMITTER: Yuan Z 

PROVIDER: S-EPMC11874230 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature