PD-L1 expression in recurrent or metastatic head and neck squamous cell carcinoma in China (EXCEED study): a multicentre retrospective study.

ABSTRACT:

Aims

Programmed death-ligand 1 (PD-L1) is known to be highly expressed in various malignancies, including head and neck squamous cell carcinoma (HNSCC). We aimed to determine the prevalence of PD-L1 expression in recurrent or metastatic HNSCC (R/M HNSCC) among Chinese patients.

Methods

This multicentre, retrospective analysis of data from six centres in China included patients with R/M HNSCC treated from 9 August 2021 to 28 February 2022. PD-L1 expression in tumour tissue was assessed and represented using a combined positive score (CPS). The χ² and Cochran-Mantel-Haenszel χ² tests were used to compare the prevalence of different PD-L1 expression statuses according to related co-variables.

Results

For all 402 examined patients with R/M HNSCC, 168

SUBMITTER: Lu H 

PROVIDER: S-EPMC11874279 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature