IQGAP3 signalling mediates intratumoral functional heterogeneity to enhance malignant growth.

ABSTRACT:

Background

The elevation of IQGAP3 expression in diverse cancers indicates a key role for IQGAP3 in carcinogenesis. Although IQGAP3 was established as a proliferating stomach stem cell factor and a regulator of the RAS-ERK pathway, how it drives cancer growth remains unclear.

Objective

We define the function of IQGAP3 in gastric cancer (GC) development and progression.

Design

We studied the phenotypic changes caused by IQGAP3 knockdown in three molecularly diverse GC cell lines by RNA-sequencing. In vivo tumorigenesis and lung metastasis assays corroborated IQGAP3 as a mediator of oncogenic signalling. Spatial analysis was performed to evaluate the intratumoral transcriptional and functional differences between control tumours and IQGAP3 knockdown tumours.

Results<

SUBMITTER: Shimura M 

PROVIDER: S-EPMC11874294 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature