Histone H3 lysine 9 tri-methylation is associated with pterygium.

ABSTRACT:

Background

Pterygium, abnormal growths of conjunctival tissue onto the cornea, are common ocular surface conditions with a high risk of recurrence after surgery and potential ophthalmic complications. The exact cause of pterygium remains unclear, and the triggers are still unknown. This study aims to investigate the relationship between pterygium and epigenetics to uncover the cause of pterygium and identify biomarkers for its diagnosis.

Methods

We performed a ChIP-seq assay to compare genome-wide histone modification levels between normal conjunctiva and stage 3 pterygium samples.

Results

In this study, we investigate the epigenetic profiles of patients with pterygium, focusing on histone H3 lysine 4 (H3K4) and lysine 9 (H3K9) trimethylation (me3). While H3K4me3 leve

SUBMITTER: Choi D 

PROVIDER: S-EPMC11874390 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature