Study on the diagnostic role of exosome-derived miRNAs in postoperative septic shock and non-septic shock patients.

ABSTRACT:

Background

Diagnosing septic shock promptly is essential but challenging, especially due to its clinical similarity to non-septic shock. Extracellular vesicle-derived miRNAs may serve as biomarkers to distinguish septic shock from non-septic shock, providing a more accurate diagnostic tool for postsurgical patients. This study aims to identify extracellular vesicle-derived miRNA signatures that differentiate septic shock from non-septic shock in postsurgical patients, potentially improving diagnostic accuracy and clinical decision-making.

Methods

A multicentre, prospective study was conducted on miRNA profiles in shock patients. Two cohorts were recruited from the Intensive Care Units of two Spanish hospitals: a discovery cohort with 109 patients and a validation cohort with

SUBMITTER: Garcia-Concejo A 

PROVIDER: S-EPMC11874436 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature