Pharmacological interventions for preventing upper gastrointestinal bleeding in people admitted to intensive care units: a network meta-analysis.

ABSTRACT:

Objectives

To assess the efficacy and safety of pharmacological interventions for preventing upper gastrointestinal (GI) bleeding in people admitted to intensive care units (ICUs).

Design and setting

Systematic review and frequentist network meta-analysis using standard methodological procedures as recommended by Cochrane for screening of records, data extraction and analysis. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach was used to assess the certainty of evidence.

Participants

Randomised controlled trials involving patients admitted to ICUs for longer than 24 hours were included.

Search methods

The Cochrane Gut Specialised Register, Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, Embase and Latin Am

SUBMITTER: Toews I 

PROVIDER: S-EPMC11874471 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature