Factors Associated With Sacubitril/Valsartan Continuation and the Methods of Combining Heart Failure Medications in Patients With Heart Failure.

ABSTRACT:

Background

Sacubitril/valsartan (SV) is recommended for patients with heart failure (HF). In addition, a combination of 4 HF medications, including SV, is recommended in patients with HF with reduced ejection fraction (HFrEF). However, evidence on the characteristics of patients who could continue SV and its initiation methods is limited.

Objective

To investigate the factors associated with SV continuation and methods of combining HF medications.

Methods

This retrospective cohort study included HF patients who initiated with SV at our institution. The endpoint was SV continuation for 6 months after its initiation. Multivariate analysis was used to extract factors associated with SV continuation. The relationship between the methods of combining HF medications (renin-a

SUBMITTER: Iwasaki E 

PROVIDER: S-EPMC11874506 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature