Atherosclerotic plaque instability in symptomatic non-significant carotid stenoses.

ABSTRACT:

Objective

Carotid endarterectomy for symptomatic carotid stenosis is recommended for patients with >70% stenosis, but not in those with <50%. Because non-significant, low-degree stenoses may still cause strokes, refined risk stratification is necessary, which could be improved by assessing biological features of plaque instability. To challenge risk-stratification based on luminal narrowing, we compared biological features of carotid plaques from symptomatic patients with low-degree (<50%) vs high-degree (>70%) stenosis and explored potential mechanisms behind plaque instability in low-degree stenoses.

Methods

Endarterectomy specimens were taken from symptomatic patients with high-degree (n = 204) and low-degree (n = 34) stenosis, all part of the Biobank of Karolinska Endart

SUBMITTER: Cyreus P 

PROVIDER: S-EPMC11874528 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature