Artemisinin alleviates cisplatin-induced damage in GC-1 spermatogonia through ER stress mechanisms.

ABSTRACT: Artemisinin, a compound derived from Artemisia annua, is primarily utilized for malaria treatment. Its mechanism of action involves the rapid and effective inhibition of protein synthesis in malarial parasites. Recently, artemisinin has garnered extensive research attention for its anticancer, antioxidant, and anti-inflammatory properties, as well as its potential role as an adjuvant in cancer treatment. Cisplatin is a commonly used anticancer agent; however, its therapeutic benefits are accompanied by side effects that negatively impact male reproductive function. In this study, the mechanism of the protective effect of artemisinin against cisplatin-induced cytotoxicity was investigated. Type B mouse spermatogonia (GC-1 spg cells), derived from mouse testes, were treated with vario

SUBMITTER: Lee R 

PROVIDER: S-EPMC11874544 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature