Blood-based biomarkers derived from tumor-informed DNA methylation analysis for lung adenocarcinoma.

ABSTRACT:

Objective

To identify robust markers of lung adenocarcinoma (LUAD) using DNA methylation profiles from blood samples informed by tissue lung adenocarcinoma.

Methods

This study analyzed 56 LUAD blood samples from patients attending clinic at Siriraj Hospital, Thailand and 51 samples from healthy participants, using 644 tumor and 59 normal tissue methylome datasets from the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) databases for candidate gene identification. We performed comparative analysis to identify DNA methylation (DNAm) changes present in tumors that are also observable in blood, to be taken forward for validation.

Results

DNAm profiling of lung tumor datasets identified 59,639 differentially methylated positions (DMPs), of which 17,251 exh

SUBMITTER: Chitta P 

PROVIDER: S-EPMC11874551 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature