Diphlorethohydroxycarmalol inhibits Muller cell gliosis by disrupting CXCR4/CXCL12 interaction in violet-blue light-induced retinal phototoxicity.

ABSTRACT: Müller gliosis is a complex process that impairs the ability of retinal Müller glial cells to respond to various forms of retinal injury or disease, leading to retinal damage. Blue light (BL) exposure is a known cause of retinal damage. In this study, we aimed to investigate the potential of DPHC in inhibiting Müller gliosis in models of BL-exposure. We conducted in silico binding analysis to evaluate the binding of DPHC to CXCR4. Then, we developed in vitro and in vivo experimental models to assess the effects of DPHC and BL exposure on Müller gliosis using MIO-M1 cells and zebrafish. Our findings show that DPHC can suppress the Müller gliosis process in BL-exposed MIO-M1 cells in vitro and in BL-exposed zebrafish in vivo. In silico molecular docking, we identified CXCR4 as

SUBMITTER: Son M 

PROVIDER: S-EPMC11874561 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature