Enhancement of Osseointegration via Endogenous Electric Field by Regulating the Charge Microenvironments around Implants.

ABSTRACT: The regulation of the charged microenvironment around implants is an effective way to promote osseointegration. Although homeostasis of the charged microenvironment plays an integral role in tissues, current research is externally invasive and unsuitable for clinical applications. In this study, functional materials with different surface potential differences are prepared by changing the spatial layout of Ta and Ag on the surface of a Ti-6Al-4V alloy (TC4). This naturally formed an endogenous electric field (EEF) with a negatively charged cell membrane after in vivo implantation and promoted osseointegration at the interface between the bone and implant through the upregulation of Ca²⁺ concentration and activation of subsequent pathways. Interestingly, the promotion of stem cel

SUBMITTER: Xu F 

PROVIDER: S-EPMC11874649 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature